Introduction The primary objective of this study was to investigate the acute anti-nociceptive/anti-hyperalgesic efficacy of Z944, a small-molecule, piperidine-based T-type calcium channel blocker efficacious in preclinical pain models, on Peak-to- Peak (PtP) amplitude reduction of Laser (radiant-heat) evoked potentials (LEPs) from Vertex-EEG compared to placebo in UV-B-inflamed and in capsaicin-irritated skin. Conclusion T-type calcium channels [...]