Introduction
The primary objective of this study was to investigate the acute anti-nociceptive/anti-hyperalgesic efficacy of Z944, a small-molecule, piperidine-based T-type calcium channel blocker efficacious in preclinical pain models, on Peak-to- Peak (PtP) amplitude reduction of Laser (radiant-heat) evoked potentials (LEPs) from Vertex-EEG compared to placebo in UV-B-inflamed and in capsaicin-irritated skin.
Conclusion
T-type calcium channels have been recognized as key targets for therapeutic intervention in a broad range of cell functions and have been implicated in pain signaling. These results represent the rst T-type calcium channel modulator to demonstrate clinical translation in pain. Based on these results, a modi ed release formulation of Z944 is being advanced through further clinical development.
As presented at the 15th world congress on pain, Buenos Aires
