Publications
Efficacy, Safety and Tolerability of Tavapadon (PF-06649751) in Subjects With Early Stage Parkinson’s Disease: A Randomized, Placebo-Controlled Trial
On Monday, 23 September, the Tavapadon team presented a poster highlighting the Tavapdon Phase 2 study data in early Parkinson's Disease at the International Congress of Parkinson’s Disease and Movement Disorders in Nice, France. [...]
First Clinical Translation of the Anti-Nociceptive/Anti-Hyperalgesic Efficacy of a T-Type Calcium Channel Modulator (Z944) Using Laser Evoked Potentials and VAS in UV-B and Capacian Irritated Skin in Healthy Humans
Introduction The primary objective of this study was to investigate the acute anti-nociceptive/anti-hyperalgesic efficacy of Z944, a small-molecule, piperidine-based T-type calcium channel blocker efficacious in preclinical pain models, on Peak-to- Peak (PtP) amplitude reduction of [...]
CSF and Plasma Monoamine Profile of the Triple-Reuptake Inhibitor SEP-432 in Healthy Volunteers
Abstract Background Based on in-vitro binding studies, SEP-432 is a triple monoamine reuptake inhibitor with a binding affinity for NE>5HT>DA. We determined the maximal tolerated dose (MTD) of SEP-432 to be 300mg/day, and in [...]
ALZ-801, a Novel Prodrug of Tramiprosate Which Improves Cognition and Function in ApoE4-Positive Alzheimer’s Disease Patients
Introduction: ALZ-801 is a novel, orally available small molecule prodrug of tramiprosate with improved pharmaceutical properties. Tramiprosate was advanced to a ~2,000 patient Phase 3 program which completed in 2007, and was deemed inconclusive by [...]
Tolerability of Oral Ziprasidone in Children and Adolescents with Bipolar Mania, Schizophrenia, or Schizoaffective Disorder
Abstract Objective This study characterizes the tolerability of ziprasidone in children and adolescents with bipolar mania, schizophrenia, or schizoaffective disorder. Method Sixty-three subjects (aged 10–17 years) entered an open-label study consisting of a 3-week [...]
Pregabalin for relief of neuropathic pain associated with diabetic neuropathy: A randomized, double-blind study
Abstract Seven published, randomized, placebo-controlled clinical trials with pregabalin have shown robust efficacy for relief of neuropathic pain from DPN and PHN. An investigation of the efficacy and safety of [...]