Publications
The AMPA Antagonist ZK 200775 in Patients with Acute Ischaemic Stroke: A Double-Blind, Multicentre, Placebo-Controlled Safety and Tolerability Study
Abstract Background and Purpose ZK 200775 is a selective competitive AMPA receptor antagonist. It has demonstrated neuroprotective efficacy in experimental models of stroke and tolerability in healthy volunteers. We tested the safety and tolerability of [...]
Concentration-Effect Relationships of Alcohol in a Computerised Psychometric Test System
Summary The purpose of this study was to validate a computerised psychometric test system by demonstrating the change of the test variables of the Bochum Diagnostic System after administration of [...]
Efficacy and tolerability of twice- daily pregabalin for treating pain and related sleep interference in postherpetic neuralgia: a 13-week, randomized trial
Objective This trial evaluated the efficacy and safety of pregabalin dosed twice daily (BID) for relief of neuropathic pain associated with postherpetic neuralgia (PHN). Research design and methods The 13week, double [...]
Pregabalin reduces pain and improves sleep and mood disturbances in patients with post-herpetic neuralgia: results of a randomised, placebo-controlled clinical trial
Abstract This study was designed to assess the efficacy and safety of pregabalin—a novel a2-d ligand with analgesic, anxiolytic, and anticonvulsant activity—for treating neuropathic pain in patients with post-herpetic neuralgia (PHN). Two hundred and [...]
Can the Expanded Disability Status Scale be assessed by telephone?
Abstract Information from patients who are unable to continue their visits to a study centre may be of major importance for the interpretation of results in multiple sclerosis (MS) clinical [...]
Test-retest reliability and influence of practice effects on performance in a multi-user computerized psychometric test system for use in clinical pharmacological studies.
Abstract Fifty naive drug-free healthy young male or female volunteers performed psychometric tests on 6 sessions with 3- to 4-days intervals, using a new multi-user computerized test system for use [...]